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Abstract One of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic oxidized to reduced forms of the nicotinamide adenine dinucleotide ratio (NAD + /NADH also known as pseudohypoxia) caused by oxidation of excessive substrates (glucose through the polyol pathway, free fatty acids and lactate)

doi: 10.1007/s12072-020-10016-2

& Horta, F

Local administration, while more direct, poses risks of tissue damage and lacks precise control over drug concentrations at the injury site, as noted by co-author Alayna Loiselle (University of Rochester)

This is a secondary-prevention result, not a general heart-health claim, and it belongs to the full obesity dose